Researchers Marwan Salih Mohamud Al-Nimer and Rozhgar Faisal Ahmed from the College of Ausool Al-Deen University in Baghdad, Iraq, investigated the efficacy of short-term diuretic treatment for resistant hypertension. In an open-label clinical study involving 120 patients, participants were treated with either a combination of amiloride and hydrochlorothiazide, spironolactone, or solely hydrochlorothiazide. All groups witnessed notable reductions in both systolic and diastolic blood pressure. Spironolactone was determined to be the most logical choice for treating resistant hypertension after a two-week regimen.
The research work was recently published in the American Journal of Drug Discovery and Development
https://doi.org/10.3923/ajdd.2017.48.53
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