This study investigates the impact of oxidative stress, induced by carbon tetrachloride (CCl4), on kidney function and the potential protective effects of Physalis angulata. Using an ethanol root extract of this plant, the study employed albino rats and assessed kidney function biomarkers. Results revealed that CCl4 significantly deteriorated renal function, leading to elevated biomarkers. However, both Physalis angulata and the standard drug (silymarin) demonstrated significant kidney protection by quenching free radicals and stabilizing vitamin C and E levels. These findings suggest the potential of Physalis angulata in reducing oxidative stress-related kidney damage.